Senior Partner · The Bracken Group

François Tranquart, MD, PhD

Physician-Scientist · Molecular Imaging & Radioligand Therapy
A physician-scientist with more than 40 years in imaging — bridging two decades of clinical practice and research at Tours University Hospital with 15+ years of industry leadership in molecular imaging, contrast media, radiopharmaceuticals, and radioligand therapy.
40+Years in Imaging
170+Peer-Reviewed Publications
20+Phase 2–4 Clinical Studies
2Imaging Compounds Approved
 

Executive Summary

Dr. François Tranquart is a physician-scientist with more than 40 years of experience in imaging, combining two decades of clinical practice and research at Tours University Hospital with over 15 years of industry leadership. His work in R&D, clinical development, and regulatory strategy has been central to the successful approval of two imaging compounds. His academic career spans oncology and cardiovascular disease, encompassing the diagnostic use of contrast media and radionuclides alongside therapy with MR-guided focused ultrasound, radionuclides, and microbubble drug delivery — work that has included 20+ Phase 2–4 clinical studies and more than 170 peer-reviewed papers.

As a Senior Partner at The Bracken Group, François advises imaging, radiopharmaceutical, and device clients on clinical development strategy, molecular imaging programs, and regulatory pathways. In industry he has led R&D and clinical development for molecular imaging and therapy using microbubbles, radiopharmaceuticals, delivery devices, software development, and contrast media manufacturing — as Global Head of Clinical Development at General Electric Healthcare Imaging, as General Manager at Bracco Suisse SA, and as Senior Consultant at Advice-US. That work has built deep experience with regulatory agencies worldwide across site inspections, clinical development pathways, studies in every phase, and NDA submissions.

Before moving into industry, François held a University Professor and Hospital Practitioner appointment in Biophysics and Nuclear Imaging at CHRU Tours and managed an INSERM team focused on ultrasound technology and its clinical applications. Clients engage François when a program needs someone who can assess genuine medical need, identify problems early, and challenge assumptions — offering contingencies and innovative strategies that turn scientific depth into a credible commercial path in molecular imaging and radioligand therapy.

 

Areas of Expertise

Molecular Imaging & Radiopharmaceuticals

R&D and clinical development of PET and SPECT tracers, radiopharmaceuticals, and molecular imaging agents — from early concept through registration and approval.

Radioligand Therapy & Theranostics

Strategy for radionuclide therapy programs that pair diagnostic imaging with targeted treatment, grounded in nuclear medicine practice and commercial development experience.

Ultrasound Contrast Media & Microbubbles

Three decades of microbubble science — agent design and performance, contrast-enhanced ultrasound, targeted agents such as BR55, and contrast media manufacturing.

Therapeutic Ultrasound & Drug Delivery

MR-guided focused ultrasound (MRgFUS), ultrasound-mediated drug delivery, and image-guided therapy — from underlying mechanism through first clinical use.

Clinical Development & Trial Design

Phase 1–4 study design and execution across oncology and cardiovascular disease, including 20+ Phase 2–4 studies and multicenter registration programs.

Regulatory Strategy & NDA Submissions

Clinical development pathways, site inspections, and NDA submissions with regulatory agencies worldwide — experience underpinning two approved imaging compounds.

 

Career History

2025 – Present
Senior Partner
The Bracken Group dba Bracken Data, Inc.
2015 – 2017 & 2024 – Present
Senior Consultant
Advice-US — Radiopharmaceuticals, Contrast Media & Regulatory Strategy
2017 – 2024
Global Head of Clinical Development
General Electric Healthcare Imaging
2009 – 2015
General Manager
Bracco Suisse SA
2000 – 2008
Team Manager
INSERM — Ultrasound Technology & Clinical Applications
1995 – 2009
University Professor & Hospital Practitioner
CHRU Tours — Biophysics & Nuclear Imaging
 

Selected Publications

  • 2023
    Flurpiridaz F-18 PET Myocardial Perfusion Imaging in Patients With Suspected Coronary Artery Disease
    Journal of the American College of Cardiology 82(16), 1598–1610 · Maddahi J, Agostini D … Tranquart F, Udelson JE.
  • 2022
    Gadolinium: Pharmacokinetics and Toxicity in Humans and Laboratory Animals Following Contrast Agent Administration
    Archives of Toxicology 96(2), 403–429 · Davies J, Siebenhandl-Wolff P, Tranquart F, Jones P, Evans P.
  • 2020
    Three Decades of Ultrasound Contrast Agents: A Review of the Past, Present and Future Improvements
    Ultrasound in Medicine & Biology 46(4), 892–908 · Frinking P, Segers T, Luan Y, Tranquart F.
  • 2017
    First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer: A Safety and Feasibility Pilot Study
    Investigative Radiology 52(7), 419–427 · Smeenge M, Tranquart F … de la Rosette JJ, Wijkstra H.
  • 2007
    First Treatment in France Using High Intensity Focalised Ultrasound for Myomas Ablation: Fiction Became Reality!
    Gynecologie, Obstetrique & Fertilite 35(9), 718–720 · Marret H, Tranquart F, Herbreteau D, Cottier JP, Bleuzen A, Body G.
  • 2001
    Quantitative Analysis of Striatal Dopamine D2 Receptors With 123I-Iodolisuride SPECT in Degenerative Extrapyramidal Diseases
    Nuclear Medicine Communications 22(11), 1207–1214 · Tranquart F.
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