CONSULTANT PUBLICATIONS

Andrew L. Salzman

MD

 

PUBLICATIONS

  1. Salzman AL, Hoffer F, Burns J: Chronic hip pain and limp in a 3-year-old girl. Reviews of Infectious Diseases 2:341-348, 1989.
  2. Jellinek MS, Todres ID, Catlin EA, Cassem EH, Salzman AL: Pediatric Intensive Care Training: Confronting the dark side. Critical Care Medicine 21:775-779, 1993.
  3. Salzman AL, Wollert PS, Wang H, Menconi MJ, Youssef ME, Compton CC, Fink MP: Intraluminal oxygenation ameliorates ischemia/reperfusion-induced gut mucosal hyperpermeability in pigs. Circulatory Shock 40:37-46, 1993.
  4. Salzman AL and Fink MP: Does gastric tonometry have a role yet in the ICU? The Journal of Critical Illness 9:131-132, 1994.
  5. Salzman AL, Strong KE, Wong H, VanderMeer TJ, Fink MP: Intraluminal balloon less "air tonometry": a new method for determination of gastrointestinal mucosal PCO2. Critical Care Medicine 22:126-134, 1994.
  6. Salzman AL, Wang H, Wollert PS, VanderMeer TJ, Compton CC, Denenberg AG, Fink MP: Endotoxin-induced ileal mucosal hyperpermeability in pigs: role of tissue acidosis. American Journal of Physiology 266: G633-G646, 1994.
  7. Salzman AL, Menconi M, Unno N, Ezzell RJ, Casey D, Fink MP: Nitric oxide dilates tight junctions and depletes ATP in cultured intestinal epithelia. American Journal of Physiology 268: G361-G373, 1995.
  8. Szabó C, Salzman AL, Ischiropolous H: Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. Federation of European Biochemical Societies Letters 363:235-238, 1995.
  9. Szabó C, Salzman AL: Endogenous peroxynitrite is involved in the inhibition of cellular respiration in immunostimulated J744.2 macrophages. Biochemical and Biophysical Research Communications 209:739-743, 1995.
  10. Szabó C, Salzman AL, Ischiropoulos H: Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. Federation of European Biochemical Societies Letters 372:229-232, 1995.
  11. Southan GJ, Szabó C, O'Connor MP, Salzman AL, Thiemermann C: Amidines are potent inhibitors of constitutive and inducible nitric oxide synthases: preferential inhibition of the inducible isoform. European Journal of Pharmacology 291:311-318, 1995.
  12. Salzman AL, Denenberg AG, Ueta I, O’Connor M, Linn S, Szabó C: Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers. American Journal of Physiology 270: G565-573, 1996.
  13. Southan GJ, Salzman AL, Szabó C: Potent inhibition of the inducible isoform of nitric oxide synthase by aminoethylisoselenourea and related compounds. Life Sciences 58:1139-1148, 1996.
  14. Southan GJ, Szabó C, Salzman AL: 2-Aminopyridines are competitive inhibitors of nitric oxide synthases. Pharmacology Communications 7:275-286, 1996.
  15. Southan GJ, Zingarelli B, O'Connor M, Salzman AL, Szabó C: Spontaneous rearrangement of aminoalkylguanidines into mercaptoalklyguanidines - a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. British Journal of Pharmacology 117:619-632, 1996.
  16. Szabó C, Bryk R, Zingarelli B, Southan GJ, Gahlman TC, Bhat V, Salzman AL, Wolff DJ: Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform. British Journal of Pharmacology 118:1659-1668, 1996.
  17. Szabó C, Day BJ, Salzman AL: Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. Federation of European Biochemical Societies Letters 381:82-86, 1996.
  18. Szabó C, Salzman AL: Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock. Shock 5:391-394, 1996.
  19. Szabó C, Salzman AL: Inhibition of terminal calcium overload protects against peroxynitrite-induced cellular injury in macrophages. Immunology Letters 51: 163-167, 1996.
  20. Szabó C, Zingarelli B, O’Connor M, Salzman AL: DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proceedings of the National Academy of Sciences 93:1753-1758, 1996.
  21. Szabó C, Zingarelli B, Salzman AL: Role of poly-ADP ribosyltransferase in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circulation Research 78:1051-1063, 1996.
  22. Unno N, Menconi MJ, Salzman AL, Smith M, Hagan S, Ge Y, Ezzel RM, Fink MP: Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers. American Journal of Physiology 270: G1010-G1021, 1996.
  23. Vromen A, Arkovitz MS, Zingarelli B, Salzman AL, Garcia VF, Szabó C: Low-level expression and limited role for the inducible isoform of nitric oxide synthase in the vascular hyporeactivity and mortality associated with cecal ligation and puncture in the rat. Shock 6:248-253, 1996.
  24.  Vromen A, Southan GJ, Szabó C, Salzman AL: Protective effects of isopropylisothiourea, an inhibitor of constitutive nitric oxide synthase in rodent and porcine hemorrhagic shock. Journal of Applied Physiology 81:707-715, 1996.
  25. Zingarelli B, O'Connor M, Wong H, Salzman AL, Szabó C: Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. Journal of Immunology 156:350-358, 1996.
  26. Zingarelli B, Salzman AL, Szabó C: Protective effects of nicotinamide against nitric oxide-mediated vascular failure in endotoxic shock: potential involvement of poly-ADP ribosyl synthetase. Shock 5:258-264, 1996.
  27. Brilli R, Krafte-Jacobs B, Smith D, Roselle D, Passerini D, Vromen A, Moore L, Szabó C, Salzman AL: Intratracheal instillation of a novel NO/nucleophile adduct selectively reduces pulmonary hypertension. Journal of Applied Physiology 83:1968-1975, 1997.
  28. Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, Szabó C: Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radical Biological Medicine 24:450-459, 1997.
  29. Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower R, Szabó C, Perretti M: Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. Journal of Immunology 159:5089-5097, 1997.
  30. Cuzzocrea S, Zingarelli B, Costantino G, Szabó A, Salzman AL, Caputi A, Szabó C: Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. British Journal of Pharmacology 121:1065-1074, 1997.
  31. Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabó C: Protective effect of melatonin in carrageenan-induced models of local inflammation: Relationship to inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. Journal of Pineal Research 23:106-116, 1997.
  32. Cuzzocrea S, Zingarelli B, O’Connor M, Salzman AL, Caputi A, Szabó C: Role of peroxynitrite and activation of poly (ADP-ribose) synthetase in the vascular failure induced by zymosan-activated plasma. British Journal of Pharmacology 122:493-503, 1997.
  33. Gardner PR, Costantino G, Szabó C, Salzman AL: Nitric oxide sensitivity of the aconitases. Journal of Biological Chemistry 272:25071-25076, 1997.
  34. Gilad E, Cuzzocrea S, Zingarelli B, Salzman AL, Szabó C: Melatonin is a scavenger of peroxynitrite. Life Sciences 60:PL169-174, 1997.
  35. Gilad E, O’Connor M, Salzman AL, Szabó C: Protection by inhibition of poly (ADP ribose) synthase against oxidant injury in cardiac myoblasts in vitro. Journal of Molecular and Cellular Cardiology 29:2585-2597, 1997.
  36. Gilad E, Zingarelli B, O'Connor M, Salzman AL, Bertók L, Szabó C: Effects of radiodetoxified endotoxin on nitric oxide production in J774 macrophages and in endotoxin shock. Journal of Endotoxin Research 3:513-516, 1997.
  37. Gilad E, Zingarelli B, Salzman AL, Szabó C: Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro. Journal Molecular Cellular Cardiology 29:2585-2597, 1997.
  38. Haskó G, Németh Z, Szabó C, Zsilla G, Salzman AL, Vizi ES: Isoproterenol inhibits 1L-10, TNF-a and nitric oxide production in RAW 264.7 macrophages. Brain Research Bulletin, 45:183-187, 1997.
  39.  Hrabák A, Bajor T, Southan G, Salzman AL, Szabó C: Comparison of the inhibitory effect of isothiourea and mercaptoalkylguanidine derivatives on the alternative pathway of arginine metabolism in macrophages. Life Sciences 60:395-401, 1997.
  40. Invernizzi P, Salzman AL, Ueta I, Denenberg A, Szabó C, O'Connor M, Setchell KDR: Ursodeoxycholic acid inhibits induction of NOS in human intestinal epithelial cells and in vivo. American Journal of Physiology 273:G131-G138, 1997.
  41. Krafte-Jacobs B, Brilli RJ, Szabó C, Denenberg A, Moore L, Salzman AL: Circulating methemoglobin, nitrate, and nitrite concentrations as indicators of nitric oxide overproduction in critically ill children with shock. Critical Care Medicine 25:1351-1355, 1997.
  42. Linn SC, Morelli PJ, Edry I, Cottongim S, Szabó C, Salzman AL: Transcriptional regulation of the human inducible nitric oxide synthase gene in an intestinal epithelial cell line. American Journal of Physiology 272:G1499-G1508, 1997.
  43. Menconi MJ, Salzman AL, Unno N, Ezzel RM, Casey DM, Tsuji Y, Fink MP: Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. American Journal of Physiology 272:G1007-G1021, 1997.
  44. Moon R, Parikh A, Szabó C, Fischer J, Salzman AL, Hasselgren PO: Complement C3 production in human intestinal epithelial cells is regulated by Il-1beta and TNF-alpha. Archives of Surgery 132:1289-1293, 1997.
  45. Németh Z, Szabó C, Haskó G, Salzman AL, Vizi ES: Effect of the PDE III inhibitor amrinone on cytokine and nitric oxide production in immunostimulated J774.1 macrophages. European Journal of Pharmacology, 339:215-221, 1997.
  46. O’Connor M, Salzman AL, Szabó C: Role of peroxynitrite in the protein oxidation and apoptotic DNA fragmentation in vascular smooth muscle cells stimulated with bacterial lipopolysaccharide and interferon-gamma. Shock 8:439-443, 1997.
  47. Parikh A, Salzman AL, Fischer JE, Szabó C, Hasselgren PO: Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock 8:249-55, 1997.
  48. Parikh A, Salzman AL, Kane CD, Fischer JF, Hasselgren PO: IL-6 Production in human intestinal epithelial cells following stimulation with IL-1b is associated with activation of the transcription factor NF-kB. Journal of Surgical Research 69:139-144, 1997.
  49. Salzman AL, Vromen A, Denenberg A, Szabó C: K-ATP channel inhibition improves hemodynamics and cellular energetics in hemorrhagic shock. American Journal of Physiology 272:H688-H694, 1997.
  50. Southan GJ, Gauld D, Lubeskie A, Zingarelli B, Cuzzocrea S, Salzman AL, Szabó C, Wolff, DJ. Inhibition of nitric oxide synthase with H- pyrazole-1- carboxamidine and related compounds. Biochemical Pharmacology 54:409-417, 1997.
  51. Szabó C, Cuzzocrea S, Lim LH, Getting S, Zingarelli B, Flower R, Salzman AL: Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. Journal of Experimental Medicine 186:1041-1049, 1997.
  52. Szabó C, Cuzzocrea S, Zingarelli B, O’Connor M, Salzman AL: Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP-ribose) synthetase (PARS) by peroxynitrite. Journal of Clinical Investigation 100:723-735, 1997.
  53.  Szabó C, Ferrer-Sueta G, Zingarelli B, Southan G, Salzman AL, Radi R: Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. Journal of Biological Chemistry 272:9030-9036, 1997.
  54. Szabó C, Haskó G, Zingarelli B, Németh Z, Salzman AL, Kvetan V, Pastores S, Vizi E: Isoproterenol regulates tumor necrosis, interleukin-10, interleukin-6, and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxemia. Immunology 90:95-100, 1997.
  55. Szabó C, Lim L, Cuzzocrea S, Getting S, Zingarelli B, Flower R, Salzman AL, Perretti M: Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. Journal of Experimental Medicine 186:1041-1049, 1997.
  56. Szabó C, O’Connor M, Salzman AL: Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophages. Federation of European Biochemical Societies Letters 409:147-150, 1997
  57. Szabó C, Saunders C, O'Connor M, Salzman AL: Peroxynitrite causes energy depletion and increases permeability via activation of poly-ADP ribosyl synthetase in pulmonary epithelial cells. American Journal of Respiratory Cell Molecular Biology 60:105-109, 1997.
  58.  Szabó C, Wong H, Bauer PI, Kirsten E, O’Connor M, Zingarelli B, Mendeleyev J, Haskó G, Sylvester E, Salzman AL, Kun E: Regulation of components of the inflammatory response by 5-iodo-6-amino-1, 2-benzopyrone, an inhibitor of poly (ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways. International Journal of Oncology 10:1093-1104, 1997.
  59. Szabó C, Wong HR, Salzman AL: Pre-exposure to heat shock inhibits peroxynitrite-induced activation of poly (ADP) ribosyl transferase and protects against peroxynitrite cytotoxicity in J774 macrophages. European Journal of Pharmacology 315:221-226, 1997.
  60.  Zingarelli B, Cuzzocrea S, Salzman AL, Szabó C: Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovascular Research. 36:205-215, 1997.
  61.  Zingarelli B, Day B, Crapo J, Salzman AL, Szabó C: The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. British Journal of Pharmacology 120:259-267, 1997.
  62.  Zingarelli B, Ischiropoulos H, Salzman AL, Szabó C: Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetized rat. European Journal of Pharmacology 338:55-75, 1997.63.    Zingarelli B, Southan G, Gilad E, O’Connor M, Salzman AL, Szabó C: The inhibitory effects of mercaptoalkylguanidines on cyclooxygenase activity. British Journal of Pharmacology 120:357-366, 1997.
  63. Zingarelli B, Southan GJ, Gilad E, O’Connor M, Salzman AL, Szabó C: Mercaptoethylguanidines are direct inhibitors of cyclooxygenase activity. British Journal of Pharmacology 120:357-366, 1997.
  64. Brahn E, Banquerigo ML, Firestein GS, Boyle DL, Salzman AL, Szabó C: Collagen-induced arthritis: reversal by mercaptoethylguanidine, a novel anti-inflammatory agent with a combined mechanism of action. Journal of Rheumatology 25:1785-1793, 1998.
  65. Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, Szabó C: Carrageenan-induced local inflammation: effect of mercaptoethylguanidine, a selective inhibitor of the inducible nitric oxide synthase and a scavenger of peroxynitrite. Free Radicals in Biology and Medicine 24:450-459, 1998.
  66. Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabó C: Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase, in a carrageenan-induced model of local inflammation. European Journal Pharmacology 342:67-76, 1998.
  67. Cuzzocrea S, Zingarelli B, O’Connor M, Salzman AL, Szabó C: Effect of Lbuthionine-(S,R)-sulfoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock - induced vascular failure. British Journal Pharmacology 123:525-537, 1998.
  68. Endres M, Scott G, Namura S, Salzman AL, Huang P, Moskowitz M, Szabó C: Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion. Neuroscience Letters 248:41-44, 1998.
  69. Endres M, Scott GS, Salzman AL, Kun E, Moskowitz M, Szabó C: Protective effects of 5-iodo-6-amino-1, 2-benzopyrone, a potent inhibitor of poly(ADP)-ribose synthetase against peroxynitrite-induced astrocyte damage and stroke development. British Journal of Pharmacology 351:377-382, 1998.
  70. Gardner PR, Gardner AM, Martin LA, Salzman AL: Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proceedings of the National Academy of Sciences 95:10378-10383, 1998.
  71. Gilad E, Wong HR, Zingarelli B, Virág L, O’Connor M, Salzman AL, Szabó C: Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NF-kappa B activation. Federation of American Societies for Experimental Biology Journal 12:685-693, 1998.
  72. Haskó G, Németh Z, Szabó C, Zsilla G, Salzman AL, Vizi ES: Isoproterenol inhibits IL-10, TNF and nitric oxide production in RAW 264.7 macrophages. Brain Research Bulletin 45: 183-187, 1998.
  73. Haskó G, Shanley T, Egnaczyk G, Németh Z, Salzman AL, Vizi S, Szabó C: Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP)1alpha via a beta-adrenoceptor mediated mechanism. British Journal of Pharmacology 125:1297-1303, 1998. 
  74. Haskó G, Szabó C, Németh ZH, Salzman AL, Vizi ES: Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent. European Journal Immunology 28:468-472, 1998.
  75. Haskó G, Szabó C, Nément ZH, Salzman AL, Vizi ES: Stimulation of beta-adrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice. Journal of Immunology 88:57-61, 1998
  76. Haskó G, Virág L, Egnaczyk G, Salzman AL, Szabó C: The crucial role of interleukin-10 in the suppression of the immumunological response in mice exposed to staphylococcal enterotoxin B. European Journal of Immunology 28:1417-1425, 1998.
  77. Parikh AA, Moon MR, Kane CD, Salzman AL, Fischer JE, Hasselgren PO: Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. Journal of Surgical Research 77:40-44, 1998.
  78. Kennedy MS, Denenberg AG, Szabó C, Salzman AL: Poly(ADP ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells. Gastroenterology 114:510-518, 1998.
  79. Lohinai Z, Benedek P, Fehér E, Györfy A, Rosivall L, Fazekas A, Zelles T, Salzman AL, Szabó C: Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase in ligature-induced periodontitis in the rat. British Journal of Pharmacology 123:353-360, 1998.
  80.  Németh Z, Haskó G, Szabó C. Salzman AL, Vizi ES: Calcium channel blockers and dantrolene differentially regulate the production of interleukin-12 and interferon-gamma in endotoxemic mice. Brain Research Bulletin 46:257-261, 1998.
  81. Salzman AL, Eaves-Pyles T, Linn SC, Denenberg AG, Szabó C: Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cells. Gastroenterology 114:93-102, 1998.
  82. Hasko G, Nemeth ZH, Vizi ES, Salzman AL, Szabó C: An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-gamma production and prevents lethality in endotoxemic mice. European Journal of Pharmacology 358:261-8, 1998.
  83. Haskó G, Szabó C, Németh Z, Salzman AL, Vizi ES: Stimulation of beta adrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice. Journal of Neuroimmunology 88:57-61, 1998.
  84. Southan GJ, Salzman AL, Szabó C: Hydroxyguanidines inhibit peroxynitrite-induced oxidation. Free Radical Biology & Medicine 25:914-925, 1998.
  85. Szabó A, Hake P, Salzman AL, Szabó C: 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, improves hemodynamics and prolongs survival in a porcine model of hemorrhagic shock. Shock 10:347-353, 1998.
  86. Szabó A, Salzman AL, Szabó C: Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxic shock. Life Sciences 63:2133-2139, 1998.
  87. Szabó C, Scott G, Virág L, Egnaczyk G, Salzman AL, Shanley T, Haskó G: Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists. British Journal Pharmacology 125:379-387, 1998.
  88. Szabó C, Virág L, Cuzzocrea S, Scott GJ, Hake P, O’Connor M, Zingarelli B, Salzman AL, Kun E: Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthetase. Proceedings of the National Academy Sciences 95:3867-3872, 1998.
  89. Gardner PR, Costantino G, Salzman AL: Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase. Journal of Biological Chemistry 273:26528-33, 1998.
  90. Pritts TA, Moon R, Fischer JE, Salzman AL, Hasselgren PO: Nuclear factor-kappa B is activated in intestinal mucosa during endotoxemia. Archives of Surgery 133:1311-5, 1998.
  91. Virág L, Haskó G, Salzman AL, Szabó C: NADPH-diaphorase histochemistry detects inducible nitric oxide synthetase activity in the thymus of naive and Staphylococcal enterotoxin B stimulated mice. Journal of Histochemical Cytochemistry & Cytochemistry 46:787-791, 1998.
  92. Virág L, Salzman AL, Szabó C: Poly (ADP-Ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. Journal of Immunology 161:3753-3759, 1998.
  93. Virág L, Scott GS, Salzman AL, Szabó C: Peroxynitrite-induced thymocyte apoptosis: the role of caspaces and poly-(ADP-ribose) synthetase (PARS) activation. Journal of Immunology 94:345-355, 1998.
  94. Zingarelli B, Salzman AL, Szabó C: Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia reperfusion injury. Circulation Research 83:85-94, 1998.
  95. Zingarelli B, Virág L, Szabó A, Cuzzocrea S, Salzman AL, Szabó C: Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase. International Journal of Molecular Medicine 1:787-795, 1998.
  96.  Bajor T, Southan GJ, Salzman AL, Szabó C, Hrabák A (1998): Theoretical approximation of the partial selectivity of sulfur-based inhibitors of nitric oxide synthase (NOS) isoenzymes. Medical Science Monitor 4:587-95.
  97. Zingarelli B, Haskó G, Salzman AL, Szabó C: Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock. Critical Care Medicine 27:1701-7, 1999.
  98. Stern Y, Salzman AL, Cotton RT, Zingarelli B: Protective effect of 3- aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against laryngeal injury in rats. American Journal of Respiratory and Critical Care Medicine 160:1743- 9, 1999.
  99. Moon R, Pritts TA, Parikh AA, Fischer JE, Salzman AL, Ryan M, Wong HR, Hasselgren PO: Stress response decreases the interleukin-1 beta-induced production of complement component C3 in human intestinal epithelial cells. Clinical Science 97:331-7, 1999.
  100. Szabó A, Hake P, Salzman AL, Szabó C: Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible isoform of nitric oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock. Critical Care Medicine 27:1343-50, 1999.
  101. Zingarelli B, Szabó C, Salzman AL: Poly(ADP-ribose) synthetase triggers a positive feedback cycle of neutrophil recruitment, oxidant generation, and mucosal injury in colitis. Gastroenterology 116:335-45, 1999.
  102. Eaves-Pyles T, Szabó C, Salzman AL: Bacterial adhesion mediates microbial activation of NF-B in enterocytes. Infection and Immunity 67: 00-4, 1999.
  103. Wilson L, Szabó C, Salzman AL: Protein kinase C-dependent activation of NF-kappa B in enterocytes is independent of IkappaB degradation. Gastroenterology 117:106-14, 1999.
  104. Zingarelli B, Szabó C, Salzman AL: Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45:199-209, 1999.
  105. Moon MR, Parikh AA, Pritts TA, Fischer JE, Cottongim S, Szabó C, Salzman AL, Hasselgren PO: Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant I-kappaB-alpha. Journal of Surgical Research 82:48-55, 1999.
  106. Kennedy M, Wilson L, Denenberg AG, Szabó C, Salzman AL: 5-ASA inhibits iNOS transcription in human enterocytes: role of IRF-1. International Journal of Molecular Medicine 4:437-43, 1999.
  107. Lorch SA, Foust R 3rd, Gow A, Arkovitz M, Salzman AL, Szabó C, Vayert B, Geffard M, Ischiropoulos H (2000): Immunohistochemical localization of protein 3- nitrotyrosine and S-nitrosocysteine in a murine model of inhaled nitric oxide therapy. Pediatric Research 47:798-805, 2000.
  108. Salzman AL, Preiser JC, Setchell K, Szabó C: Isoflavone-mediated inhibition of tyrosine kinase: a novel anti-inflammatory approach. Journal of Medicinal Food 2:179-81, 2000.
  109. Parikh AA, Moon MR, Pritts TA, Fisher JE, Szabó C, Hasselgren PO, Salzman AL: IL-1beta induction of NF-kB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock 13:8-13, 2000.
  110. Wilmott RW, Kitzmiller JA, Szabó C, Southan GJ, Salzman AL: Mercaptoethylguanidinine reduces the inflammatory response in a murine model of chronic infection with Pseudomonas aeruginosa. Journal of Pharmacology and Experimental Therapeutics 292:88-95, 2000.
  111. Haskó G, Kuhel DG, Salzman AL, Szabó C: ATP suppression of interleukin-12 and tumour necrosis factor-alpha release from macrophages. British Journal of Pharmacology 129:909-14, 2000.
  112. Haskó G, Kuhel DG, Németh ZH, Mabley JG, Stachlewitz RF, Virág L, Lohinai Z, Southan GJ, Salzman AL, Szabó C: Inosine inhibits inflammatory cytokine production by a post-transcriptional mechanism and protects against endotoxic shock. Journal of Immunology 164:1013-9, 2000.
  113. Zingarelli B, Scott GS, Hake P, Salzman AL, Szabó C: Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. Shock 13:126-34, 2000.
  114. Pritts TA, Moon MR, Wang Q, Hungness ES, Salzman AL, Fischer JE, Hasselgren PO. Activation of NF-kappaB varies in different regions of the gastrointestinal tract during endotoxemia. Shock 14:118-22, 2000.
  115. Soejima K, McGuire R, Snyder N, Uchida T, Szabó C, Salzman AL, Traber LD, Traber DL: The effect of inducible nitric oxide synthase inhibition on smoke inhalation injury in sheep. Shock 13:261-6, 2000.
  116. Liaudet L, Szabó A, Soriano FG, Zingarelli B, Szabó C, Salzman AL: Poly (ADP-ribose) synthetase activation mediates intestinal mucosal barrier dysfunction after mesenteric ischemia. Shock 14:134-41, 2000.
  117. Salzman AL, Denenberg A, Linn SC, Szabó C: Progesterone inhibits inducible nitric oxide synthase mRNA expression in human epithelial cells. International Journal of Molecular Medicine 6:209-16, 2000.
  118. Bernstein T, Szabó C, Salzman AL: Maturation-dependent sequential expression of interferon regulatory factor-1 and inducible nitric oxide synthase in cultured human enterocytes. Shock 14:514-21, 2000.
  119. Liaudet L, Soriano FG, Szabó E, Virág L, Mabley JG, Salzman AL, Szabó C: Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose) polymerase. Proceedings of the National Academy of Sciences 97:10203-8, 2000.
  120. Soriano FG, Virág L, Jagtap P, Szabó É, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KGK, Salzman AL, Southan GJ, Szabó C: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nature Medicine 7:108-13, 2001.
  121. Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabó C, Szabó É, Virag L, Salzman AL, Traber DL: Nebulized NO/nucleophile reduces pulmonary vascular resistance in mechanically ventilated septic sheep. American Journal of Respiratory and Critical Care Medicine 163:745-52, 2001.
  122. Eaves-Pyles T, Murthy K, Liaudet L, Virag L, Ross G, Soriano FG, Szabó C, Salzman AL: Flagellin: a novel mediator of Salmonella-induced Epithelial Activation and systemic Inflammation: IkappaB-alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. Journal of Immunology 166:1248-60, 2001.
  123. Mabley JG, Liaudet L, Pacher P, Southan GJ, Salzman AL, Szabó C: Beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis. Molecular Medicine 8: 581-90, 2002.
  124. Liaudet L, Szabó C, Evgenov O, Murthy KG, Pacher P, Virág L, Mabley J, Marton A, Soriano FG, Kirov M, Bjertnaes LJ, Salzman AL: Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock 19:131-7, 2003.
  125. Mabley JG, Liaudet L, Pacher P, Soriano FG, Haskó G, Marton A, Salzman AL, Szabó C: Inosine reduces inflammation and improves survival in a murine model of colitis. American Journal of Physiology 284:G138-44, 2003.
  126. Naidu BV, Fraga C, Salzman AL, Szabó C, Verrier ED, Mulligan MS: Critical role of reactive nitrogen species in lung ischemia-reperfusion injury. Journal of Heart and Lung Transplantation 22:784-93, 2003.
  127. Mabley JG, Soriano FG, Pacher P, Haskó G, Marton A, Wallace R, Salzman AL, Szabó C: The adenosine A3 receptor agonist N6-(3-iodobenzyl)-adenosine-5’-Nmethyluronamide, reduces inflammation and oxidative damage in two murine models of colitis. European Journal of Pharmacology, 466:323-329, 2003.
  128. Evgenov OV, Pacher P, Williams W, Evgenov NV, Mabley JG, Cicila J, Síkó ZB, Salzman AL, Szabó C: Intramuscular administration of glipizide, an inhibitor of ATP-sensitive potassium channels prolongs survival after severe controlled hemorrhage in rats. Critical Care Medicine, 31:2429-2436, 2003.
  129. Mabley JG, Suarez-Pinzon WL, Haskó G, Pacher P, Power R, Southan GJ, Salzman AL, Rabinovich A, Szabó C: Inosine protects against diabetes development in multiple low dose streptozotocin and NOD mouse models of type I diabetes. Molecular Medicine 9:96-104, 2003.
  130. Shimoda K, Murakami K, Traber LL, Cox RA, Hawkins HK, Schmalstieg FC, Szabó C, Salzman AL, Traber DL: Effect of poly(ADP-ribose) synthetase inhibition on burn and smoke inhalation injury in the sheep. American Journal of Physiology 285:L240-L249, 2003.
  131. Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL, Boons GJ, Leibovich SJ: An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. American Journal of Pathology 163:711-21, 2003.
  132. Naidu BV, Farivar AS, Woolley SM, Fraga C, Salzman AL, Szabó C, Groves JT, Mulligan MS: Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis. Experimental Molecular Pathology 75:12-7, 2003.
  133. Komjáti K, Mabley JG, Virág L, Southan GJ, Salzman AL, Szabó C: Poly(ADP-ribose) polymerase inhibition protects neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. International Journal of Molecular Medicine 13:373-382, 2004.
  134. Jagtap P, Southan GJ, Baloglu E, Ram S, Mabley JG, Marton A, Salzman AL, Szabó C: The discovery and synthesis of adenosine substituted 2,3-Dihydro-1H-isoindol-1- ones: Potent Inhibitors of PARP-1. Bioorganic and Medicinal Chemistry Letters 5:81-85, 2004.
  135. Pacher P, Mabley JG, Liaudet L, Evgenov OE, Southan GJ, Szabó C, Salzman AL: Topical administration of a novel nitric oxide donor, DS1, selectively increases vaginal blood flow in anesthetized rats. International Journal of Impotence Research 15:461-464, 2003.
  136. Murthy KGK, Deb A, Goonesekera S, Szabó C, Salzman AL: Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro. Journal of Biological Chemistry 279:5667-5675, 2004.
  137. Mabley JG, Southan GJ, Salzman AL, Szabó C: The combined inducible nitric oxide synthase inhibitor and free radical scavenger, guanidinoethyldisulphide, prevents multiple-low-dose-streptozotocin-induced diabetes in vivo and interleukin-1ß-induced suppression of islet insulin secretion in vitro. Pancreas 28:E39-E44, 2004.
  138. Mabley JG, Pacher P, Haskó G, Southan GJ, Salzman AL, Szabó C: Inosine protects against development of collagen-induced rheumatoid arthritis. J Autoimmunity, in press, 2004.
  139. Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Hawkins HK, Chandra A, Mizutami A, Schmalstieg FC, Salzman AL, Szabó C, Traber DL: Inhibition of poly (ADP-ribose) synthetase attenuates lung injury in an ovine model of sepsis. Shock 21:126-133, 2004.
  140. Woolley SM, Farivar AS, Naidu BV, Salzman A, Szabó C, Thomas R, Fraga C, Mulligan MS. Role of poly (ADP) ribose synthetase in lung ischemia-reperfusion injury. J Heart Lung Transplant 23:1290-6, 2004.
  141. Maybauer DM, Salsbury JR, Westphal M, Maybauer MO, Salzman AL, Szabó C, Westphal-Varghese BB, Traber LD, Traber DL. The ATP-sensitive potassium-channel inhibitor glibenclamide improves outcome in an ovine model of hemorrhagic shock. Shock 22:387-91, 2004.
  142. Farivar AS, Woolley SM, Naidu BV, Fraga CH, Byrne K, Thomas R, Salzman AL, Szabó CS, Mulligan MS. Poly (ADP) ribose synthetase inhibition reduces obliterative airway disease in rat tracheal allografts. J Heart Lung Transplant 23:993-1002, 2004.
  143. Murthy KG, Szabó C, Salzman AL. Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase. Inflamm Res 53:604-8, 2004.
  144. Farivar AS, Woolley SM, Fraga CH, Thomas R, Salzman AL, Szabó C, Mulligan MS. Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury. Ann Thorac Surg 77:1938-43, 2004.
  145. Cheng CL, Johnson SP, Keir ST, Quinn JA, Ali-Osman F, Szabó C, Li H, Salzman AL, Dolan ME, Modrich P, Bigner DD, Friedman HS. Poly (ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. Mol Cancer Ther 4:1364-8, 2005.
  146. Jagtap PG, Baloglu E, Southan GJ, Mabley JG, Li H, Zhou J, van Duzer J, Salzman AL, Szabó C. Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem 48:5100-3, 2005.
  147. Neville LF, Barnea Y, Hammer-Munz O, Gur E, Kuzmenko B, Kahel-Raifer H, Eren R, Elkeles A, Murthy KG, Szabó C, Salzman AL, Dagan S, Carmeli Y, Navon-Venezia S. Antibodies raised against N'-terminal Pseudomonas aeruginosa flagellin prevent mortality in lethal murine models of infection. Int J Mol Med 16:165-71, 2005.
  148. Jagtap PG, Baloglu E, Southan G, Williams W, Roy A, Nivorozhkin A, Landrau N, Desisto K, Salzman AL, Szabó C. Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one. Org Lett 28:1753-6, 2005.
  149. Bjertnaes LJ, McGuire R, Jodoin J, Salzman AL, Traber LD, Passerini DJ, Smith DJ, Szabó C, Traber DL. Nebulized nitric oxide/nucleophile adduct reduces pulmonary vascular resistance in mechanically ventilated septicemic sheep. Crit Care Med 33:616-22, 2005.
  150. Lange M, Szabó C, Van Aken H, Williams W, Traber DL, Daudel F, Bróking K, Salzman AL, Bone HG, Westphal M. Short-term effects of glipizide (an adenosine triphosphate-sensitive potassium channel inhibitor) on cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheep. Shock. 26:516-21, 2006.
  151. Morrow DA, Brickman CM, Murphy SA, Baran K, Krakover R, Dauerman H, Kumar S, Slomowitz N, Grip L, McCabe CH, Salzman AL. A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial. J Thromb Thrombolysis 2008.
  152. Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C. The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes. J Endocrinol 198:581-9, 2008.
  153. Maybauer DM, Maybauer MO, Szabo C, Westphal M, Traber LD, Enkhbaatar P, Murthy KG, Nakano Y, Salzman AL, Herndon DN, Traber DL. Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity. Biochem Biophys Res Commun 377:786-91, 2008.
  154. Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabó C. The novel inosine analogue, INO-2002, exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock 32:258-262, 2009.
  155. Maybauer DM, Maybauer MO, Szabó C, Cox RA, Westphal M, Kiss L, Horvath EM, Traber LD, Hawkins HK, Salzman AL, Southan GJ, Herndon DN, Traber DL. The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock. Shock 35:148-55. 2011.
  156. Maybauer DM, Maybauer MO, Szabó C, Westphal M, Traber LD, Salzman AL, Herndon DN, Traber DL. The peroxynitrite catalyst WW-85 improves microcirculation in ovine smoke inhalation injury and septic shock. Burns 37:842-50, 2011
  157. Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabó C. Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol 2018 Jan;175(2):192-222.
  158. Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N. CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis. J Clin Invest 2017 Oct 2;127(10):3913.
  159. Henning SW, Fernandez MF, Mahon JP, Duff R, Azarafrooz F, Guevara-Patiño JA, Rademaker AW, Salzman AL, Le Poole IC. HSP70iQ435A-encoding DNA repigments vitiligo lesions in Sinclair swine. J Invest Dermatol 2018 Dec;138(12):2531-2539.
  160. Ito H, Malgerud E, Asmussen S, Lopez E, Salzman AL, Enkhbaatar P. R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis. J Transl Med 2017 Dec 28;15(1):266.