Senior Partner · The Bracken Group

Jeffrey Cottrell, PhD

CNS Drug Discovery · Translational Neuroscience · Neurogenetics
Neuroscientist with 20 years in CNS drug discovery across biotech startups, the Broad Institute, and Novartis, translating the genetics of brain disorders into therapeutic programs.
20+Years in CNS Drug Discovery
4Patent Filings
29Scientists Led at Novartis
$11MResearch Budget at the Broad

Executive Summary

Jeffrey (Jeff) Cottrell, PhD, is a Senior Partner at The Bracken Group and a neuroscientist with 20 years of experience in CNS research and drug discovery. He earned his PhD in Neuroscience from MIT in 2004 and has dedicated his career to uncovering the basis of brain disorders and finding treatments for them, working across neurodegenerative, psychiatric, and neurodevelopmental disease.

Jeff spent eleven years at Galenea, a CNS startup where he was the first hire, leading development of a proprietary platform for measuring synaptic function in a high-throughput fashion. He then became Director of Translational Research at the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, translating the genetics of brain disorders into therapeutic projects, one of which was out-licensed to a pharma company. At Novartis he led systems neuroscience drug discovery across small molecule, AAV, and siRNA programs.

Between those roles he was the first employee at Delix Therapeutics, where a virtual discovery program he built reached IND approval and the clinic in 2023, and an early leader at Serqet Therapeutics. He holds four patent filings, has published widely on cellular and molecular neurobiology, and now advises companies through JCNeuro Consulting and Bracken.

Intellectual Property

WO 2019/035034 · 2018
Neuronal Assay Method Involving Calcineurin
Li L, Zhang Y-L, Ghoshal A, Cottrell JR.
WO 2018/118808 · 2018
Methods of Treating Autism Spectrum Disorders
Madison J, Cottrell JR.
US 15/260,262 · 2016
Use of Paralog-Selective Inhibitors of GSK3 Kinases
Scolnick EM, Cottrell JR, Wagner FF, … Heynen A.
WO 2010/027446 · 2010
Synaptic Vesicle Cycling Assays and Systems
Gerber DJ, Cottrell JR, Ryan TA, Levenson JM.

Areas of Expertise

CNS Drug Discovery

Neurodegenerative, psychiatric, and neurodevelopmental programs from target selection to lead optimization across small molecule, AAV, and siRNA.

Genetics-Driven Target Selection

Translating the human genetics of brain disorders into novel targets and a precision strategy built on neural circuitry.

Synaptic Biology & Screening

High-throughput physiology assays of synaptic function in primary neurons, plus biochemical and cell-based screening.

Translational Biomarkers

Mechanism of action research and human biomarker development to advance programs into early clinical trials.

Biotech Startup Building

First hire or first employee at three startups, setting scientific strategy, budgets, hiring plans, and fundraising.

Rare Neurodevelopmental Disorders

SCN2A, Fragile X syndrome, and autism spectrum disorders, including scientific advisory work with patient foundations.

Career History

Current
Senior Partner
The Bracken Group
2024 – Present
Founder & Lead Consultant
JCNeuro Consulting, LLC
Strategy and experimental design for neurodegenerative, psychiatric, and neurodevelopmental programs.
2021 – 2024
Head of Systems Neuroscience
Novartis Institutes for BioMedical Research
Unit head for small molecule, AAV, and siRNA programs; led up to 29 scientists and sat on the Neuroscience Leadership Team.
2021
Senior Director, Neurobiology
Serqet Therapeutics
Built a translational biology team to take genetically selected targets into drug discovery for neurodegeneration.
2020
Vice President, Discovery
Delix Therapeutics
First employee; set scientific strategy, managed an $8.5M budget, and built the program that reached IND in 2023.
2015 – 2020
Director, Translational Research, Stanley Center for Psychiatric Research
Broad Institute of MIT and Harvard
Co-led 20 scientists, managed an $11M budget, and advanced a program to out-licensing.
2004 – 2015
Associate Scientist to Director, In Vitro Pharmacology
Galenea Corporation
First hire; built a high-throughput synaptic physiology platform and led a team of up to 11.

Career Milestones

  • IND
    Virtual drug discovery program that reached IND approval and clinical trials in 2023
    Delix Therapeutics
  • Licensing
    Program advanced from target selection to lead optimization and out-licensed to a pharma company
    Broad Institute
  • Partnering
    Scientific strategy that produced four multimillion-dollar pharma collaborations
    Galenea Corporation
  • Industry
    $1.5M-per-year industry collaboration on the mechanism of action of an Alzheimer’s and Fragile X therapeutic
    Broad Institute
  • Funding
    $4.5M NIH grant, plus co-principal investigator on a multi-year R01
    Galenea Corporation · Broad Institute
  • Strategy
    Genetics-rooted precision CNS drug discovery strategy built on neural circuitry
    Novartis

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