James Gilligan




  1. Mehta N, Gilligan J, Stern W, Technologies and Clinical Studies for The Oral Delivery of Calcitonin. Copyright 2017 Frederick Furness Publishing Ltd p.10-15.


  1. Wells G, Chernoff J, Gilligan JP, Krause DS. Does salmon calcitonin cause cancer? A review and meta-analysis. Osteoporos Int. 2016 Jan;27(1):13-9. doi: 10.1007/s00198-015-3339-z. Epub 2015 Oct 5. Review. PubMed PMID: 26438308; PubMed Central PMCID: PMC4715844.


  1. Binkley N, Bone H, Gilligan JP, Krause DS. Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial. Osteoporos Int. 2014 Nov;25(11):2649-56. doi: 10.1007/s00198-014-2796-0. Epub 2014 Jul 16. PubMed PMID: 25027109; PubMed Central PMCID: PMC4203997.


  1. Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N, Perretti M. The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. PLoS One. 2013;8(2):e54299. doi: 10.1371/journal.pone.0054299. Epub 2013 Feb 5. PubMed PMID: 23393556; PubMed Central PMCID: PMC3564948.


  1. Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS; Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators. A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial. J Bone Miner Res. 2012 Aug;27(8):1821-9. doi: 10.1002/jbmr.1602. PubMed PMID: 22437792.


  1. Mehta NM, Malootian A, Gilligan JP. Calcitonin for osteoporosis and bone pain. Curr Pharm Des. 2003;9(32):2659-76. Review. PubMed PMID: 14529539.


  1. Sinko PJ, Lee YH, Makhey V, Leesman GD, Sutyak JP, Yu H, Perry B, Smith CL, Hu P, Wagner EJ, Falzone LM, McWhorter LT, Gilligan JP, Stern W. Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT). Pharm Res. 1999 Apr;16(4):527-33. PubMed PMID: 10227707.


  1. Valentijn K, Gutow AP, Troiano N, Gundberg C, Gilligan JP, Vignery A. Effects of calcitonin gene-related peptide on bone turnover in ovariectomized rats. Bone. 1997 Sep;21(3):269-74. PubMed PMID: 9276092.


  1. Sinko PJ, Smith CL, McWhorter LT, Stern W, Wagner E, Gilligan JP. Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats. J Pharm Sci. 1995 Nov;84(11):1374-8. PubMed PMID: 8587058.


  1. Gilligan JP, Lovato SJ, Erion MD, Jeng AY. Modulation of carrageenan-induced hind paw edema by substance P. Inflammation. 1994 Jun;18(3):285-92. PubMed PMID: 7522223.


  1. Ray MV, Van Duyne P, Bertelsen AH, Jackson-Matthews DE, Sturmer AM, Merkler DJ, Consalvo AP, Young SD, Gilligan JP, Shields PP. Production of recombinant salmon calcitonin by in vitro amidation of an Escherichia coli produced precursor peptide. Biotechnology (N Y). 1993 Jan;11(1):64-70. PubMed PMID: 7763486.


  1. Shields PP, Gonzales TA, Charles D, Gilligan JP, Stern W. Accumulation of pepstatin in cultured endothelial cells and its effect on endothelial processing. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1006-12. PubMed PMID: 2059194.


  1. Gilligan JP, Lovato SJ, Jeng AY. Modulation of endogenous levels of substance P in rat CNS tissues by N, N-diethyldithiocarbamate. Ann N Y Acad Sci.1991; 632:394-5. PubMed PMID: 1719885.


  1. Jeng AY, Wong M, Lovato SJ, Erion MD, Gilligan JP. A radioimmunoassay for measuring alpha-amidating enzyme activity. Anal Biochem. 1990 Mar;185(2):213-9. PubMed PMID: 1692669.


  1. Tamburini PP, Koehn JA, Gilligan JP, Charles D, Palmesino RA, Sharif R, McMartin C, Erion MD, Miller MJ. Rat vascular tissue contains a neutral endopeptidase capable of degrading atrial natriuretic peptide. J Pharmacol Exp Ther. 1989 Dec;251(3):956-61. PubMed PMID: 2532252.


  1. Gilligan JP, Lovato SJ, Mehta NM, Bertelsen AH, Jeng AY, Tamburini PP. Multiple forms of peptidyl alpha-amidating enzyme: purification from rat medullary thyroid carcinoma CA-77 cell-conditioned medium. 1989 Jun;124(6):2729-36. PubMed PMID: 2721443.


  1. Tamburini PP, Jones BN, Consalvo AP, Young SD, Lovato SJ, Gilligan JP, Wennogle LP, Erion M, Jeng AY. Structure-activity relationships for glycine-extended peptides and the alpha-amidating enzyme derived from medullary thyroid CA-77 cells. Arch Biochem Biophys. 1988 Dec;267(2):623-31. PubMed PMID: 3145718.


  1. Mehta NM, Gilligan JP, Jones BN, Bertelsen AH, Roos BA, Birnbaum RS. Purification of a peptidylglycine alpha-amidating enzyme from transplantable rat medullary thyroid carcinomas. Arch Biochem Biophys. 1988 Feb 15;261(1):44-54. PubMed PMID: 3341777.


  1. Jones BN, Tamburini PP, Consalvo AP, Young SD, Lovato SJ, Gilligan JP, Jeng AY, Wennogle LP. A fluorometric assay for peptidyl alpha-amidation activity using high-performance liquid chromatography. Anal Biochem. 1988 Feb 1;168(2):272-9. PubMed PMID: 3364727.


  1. Gilligan JP, Langner RO. Effect of removal of atherogenic diet on protein synthesis and cholesterol retention in rabbit aorta and lung. 1985 Jan;54(1):1-10. PubMed PMID: 3994775.


  1. Gilligan JP, Spector S. Synthesis of collagen in cardiac and vascular walls. Hypertension. 1984 Nov-Dec;6(6 Pt 2):III44-9. Review. PubMed PMID: 6240453.


  1. Jones BN, Gilligan JP. o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr. 1983 Aug 26;266:471-82. PubMed PMID: 6630358.


  1. Hahn EF, Martucci CP, Gilligan JP, Spector S. Early exposure to naloxone increases blood pressure in normotensive and hypertensive rats. Biochem Biophys Res Commun. 1982 Jul 30;107(2):707-13. PubMed PMID: 7126236.